Patients with severe VVS -Vulvar Vestibulitis Syndrome- associated with HPV -Human Papilloma Virus- infections, may benefit from local a-interferon injections into the affected areas. Discomfort from the injections is kept at a minimum by numbing the area with 5% Lidocaine gel prior to using a very fine needle.

Interferon is an anti-viral immunomodulator.

Injections are given twice weekly over 8 weeks.

The full response usually occurs 2 months after the completion of therapy.

The most common side effects are flu-like symptoms with the first couple injections.